ABSTRACT
Introduction: Invasive fungal infections other than theCandida species and Aspergillus species are becomingcommon in the nosocomial setting particularly among theimmunocompromised patients but there is a hinderance intheir accurate diagnosis. Aim of our study was to know theprevalence of rare fungal species and to know the patientsoutcome in our region. Aim of our study is to know theprevalence of rare fungal species and to know the patientsoutcome in our region.Material amd Methods: The present study was carried outon the patients attending outpatient department and inpatientdepartment of T.B. and Respiratory Diseases, along with thoseattending antiretroviral treatment clinic and ICTC (Departmentof Microbiology), in J. N. Medical College, AMU during theperiod of January 2015 to October 2016.Results: Majority of the cases i.e., 47 (31.3%) were between31-40 years with a mean age of 32.5 years. Of 65 isolates,Cryptococcus neoformans and Pneumocystis jiroveciirepresented 2 (6.1%) isolates each, all of which were foundin HIV positive cases. 1 (3.1%) isolate of Mucor from adiabetic patient and 1 (3.1%) isolate of Penicillium marneffeifrom an HIV positive patient as detected. Cryptococcus andPneumocystis jirovecii were isolated from both patients withCD4 count< 200. and 114(+19.9) respectively.Conclusions: Invasive fungal infections other than thecandidia species and aspergillus species are becoming verycommon now a days.
ABSTRACT
Introduction: Incidence of invasive fungal infections is now rising. An estimated 4.7 million HIV-1–infected persons are living in Asia. The aim of the study was to know the anti fungal susceptibility profile of Candida spp. and Aspergillus spp.in northen India region. Material and methods: In this study we took 150 patients attending outpatient department and admitted in the wards of T.B. and Respiratory Diseases, along with those attending antiretroviral treatment clinic and ICTC (Department of Microbiology), in J. N. Medical College, AMU. Results: Amongst Candida isolates, resistance to fluconazole was seen in 6.9% isolates of C. albicans. 50% of C. dubliniensis and 20% of C.glabrata were resistant to fluconazole. Also, resistance to ketoconazole was observed in 25% isolates of C. dubliniensis. Only 1 isolate was resistant to AMB which was of C.glabrata (20%) and no isolate was resistant to Caspofungin. Resistance to Amphotericin B was seen in 11.8% of A. fumigatus, 10% of A. flavus and 33.3% of A. niger. Resistance to Itraconazole was found in 11.8% of A. fumigatus, 20% of A. flavus and 33.3% of A. niger. Resistance to Ketoconazole was seen in 11.1% of A. fumigatus, 14.2% of A. flavus and 100% of A. niger. No resistance was seen against Caspofungin against any species of Aspergillus. Conclusion: There is gradual increase in the antifungal resistance among higher drugs reported from other regions, is a major concern for today.